In this talk, Nima Arkani-Hamed, Professor in the School of Natural Sciences, discusses the direction of fundamental physics in coming years and decades, including efforts to replace the concept of spacetime and understand how the macroscopic world is formed by microscopic quantum mechanical laws. A key influence in the search for answers will be a new "golden age" of experiments, including the Large Hadron Collider. The lecture was part of the Institute for Advanced Study's celebration of its eightieth anniversary.