One of the biggest discoveries of humankind is yet to come: Finding compelling evidence for life on another planet. In this lecture, Hanno Rein, former Member (2010–13) in the School of Natural Sciences, discusses the many places to look for biosignatures, both in the Solar System and beyond. Additionally, Rein explains why chances are good for finding an Earth-twin planet around a Sun-like star within the next few years, as well as the challenges faced when that planet is discovered.