Workshop on Topology: Identifying Order in Complex Systems

How to describe, analyze and interrogate dynamics of gene regulatory networks

We first describe mathematical foundation of DSGRN (Dynamic Signatures Generated by Regulatory Networks), an approach that provides a queryable description of global dynamics of a network over its entire param- eter space. We describe a connection to Boolean network models that allows us to view DSGRN as a platform for bifurcation theory of Boolean maps.

We describe several applications. We show how to use DSGRN to (1) design a network that performs a biological function; (2) diagnose why a synthetic network failed, and (3) delineate dynamics of network that governs epithelial-mesenchynal transition, which allows cells to escape confinement of a tissue and migrate.

Date & Time

October 23, 2020 | 2:00pm – 3:30pm

Location

Remote Access - see Zoom link below

Speakers

Tomas Gedeon

Affiliation

Montana State University

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